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Custom Synthesis

We provide custom synthesis PEGs of various molecular weights (MW) and functionalities.

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Poly(ethylene glycol)–distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers are biocompatible and amphiphilic polymers that can be widely utilized in the preparation of liposomes, polymeric nanoparticles, polymer hybrid nanoparticles, solid lipid nanoparticles, lipid–polymer hybrid nanoparticles, and microemulsions. Particularly, the terminal groups of PEG can be activated and linked to various targeting ligands, which can prolong the circulation time, improve the drug bioavailability, reduce undesirable side effects, and especially target specific cells, tissues, and even the intracellular localization in organelles.

 

 

Carboxyl-terminated PEG-DSPE

Carboxyl groups are introduced to the terminal groups of PEG-DSPE block copolymers, which can easily react with the ligands for active target cells or tissues, such as transferring and peptide.9–11 Several reports have successfully synthesized DSPE-PEG-COOH.12–14 In brief, DSPE in chloroform methanol was added to PEG-bis(succinimidyl succinate) (PEG-2OSu) in chloroform, followed by the addition of triethylamine. The reaction mixture was stirred vigorously overnight at room temperature. Full conversion of the primary amino group of DSPE was confirmed by the negative ninhydrin reactivity after separating the products by thin-layer chromatography.

 

 

However, delivery of molecular therapeutics efficiently and specifically to the targeted tissue remains a significant challenge.

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